Hydrocortisone Acetate

Hydrocortisone Acetate

Title:

Description:

Hydrocortisone Acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.

Application: For R&D Purpose.
WARNING! This product is not for human or veterinary use.
Need larger quantities for your development, manufacturing or research applications? Contact us.

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  • Overview
  • Product Description
  • Safety
  • Packaging & Delivery
  • Shipping & Payment FAQ
  • Environmental
Technical Information


Synonyms: 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate, 17-α-Hydroxycorticosterone acetate, 17-Hydroxycorticosterone 21-acetate, 21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione, 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate, 17α-Hydroxycorticosterone acetate
CAS No: :50-03-3
Molecular formula: C23H32O6
Molecular weight: 404.50 g/mol
Purity: :98%
Appearance: White to Off-White Solid
Melting point: 223 ºC
Boiling Point: 576.6±50.0 C° (at 760 mmHg)
Flash Point: 196.2±23.6 C°
Formulation: A neat solid powder
SMILES:CC(=O)OCC(=O)[[email protected]]1(CC[[email protected]@H]2[[email protected]@]1(C[[email protected]@H]([[email protected]]3[[email protected]]2CCC4=CC(=O)CC[[email protected]]34C)O)C)O
InChi Key: ALEXXDVDDISNDU-JZYPGELDSA-N
Grade Standard: Pharmaceutical-grade
Brand name: Ikigai ™
Standard: USP, Ph. Eur., JP Etc

Shipping & Storage Information

Storage: -20°C
Shipping: Room Temperature (may vary elsewhere)
Stability (shelf life): ≥ 2 years
Origin: PRC

The suggested storage temperature is at -20℃, but the package is usually shipped at room temperature.
1. By “the suggested storage temperature is at -20℃”, it means need to keep the left compound at -20℃ after the package was opened and the API could not be used for a prolonged period of time.
2. Most of our APIs are in dry powder and have very good stability, so it is safe during the transition at room temperature and it could last for 1-2 weeks and even more.
3. For some specific sensitive compounds, we will ship them with dry ice or blue ice bags.
Uses

EPA CPDat Chemical and Product Categories

Category Category Description Categorization Type
Drug Drug product, or related to the manufacturing of drugs; modified by veterinary, animal, or pet if indicated by a source CPCat Cassette
Drug, dea_abuse_concern Pharmaceutical related CPCat Cassette
Human_metabolite Human metabolites CPCat Cassette
General Manufacturing Information

Various enzymic transformation of progesterone with Rhizopus nigricans .The progesterone derivative are supplemented to the fermentation medium and transformations were assayed at 24 and 48 hr.

Technological superiority and innovation
API manufacturing
GHS Classification
Pictogram(s)
Acute Toxic
Irritant
Health Hazard
Signal
Danger
GHS Hazard Statements Aggregated GHS information provided by 90 companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 1 of 90 companies. For more detailed information, please visit ECHA C&L website

Of the 16 notification(s) provided by 89 of 90 companies with hazard statement code(s):

H300 (42.7%): Fatal if swallowed [Danger Acute toxicity, oral]

H319 (12.36%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H360 (35.96%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H361 (16.85%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H373 (39.33%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes P201, P202, P260, P264, P270, P280, P281, P301+P310, P305+P351+P338, P308+P313, P314, P321, P330, P337+P313, P405, and P501

(The corresponding statement to each P-code can be found at the GHS Classification page.)

Accidental Release Measures

Disposal Methods
SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEAEPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state-licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Toxicity Values
Organism Test Type Route Dose Effect Reference
rat LDLo subcutaneous 250 mg/kg (250 mg/kg) Arzneimittel-Forschung. Drug Research., 27(2102), 1977 [PMID:580008]
mouse LD50 intraperitoneal 2300 mg/kg (2300 mg/kg) Compilation of LD50 Values of New Drugs.
mouse LD50 subcutaneous 45050 ug/kg (45.05 mg/kg) National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program., JAN1986
Supply Ability:

2000 Metric Ton/Metric Tons per Month

Packaging & Delivery

Packing: Export worthy packing (1kg/Aluminium foil bag;25kg/drum) Or as per customers request.
Ports: port of Hong Kong HKSAR of PRC.,  port of Ningbo, PRC or Any port in China.
Delivery methods:

By couriers:

Question 1: How to start orders for API materials?

Answer: Pro-forma invoice will be sent first after confirmation of the order, enclosed our payment information. Payment by T/T, Paypal, and others. All courier tracking numbers are provided upon shipping.

Question 2: What’s your MOQ?

Answer: The MOQ for this API is 1kg.

Question 3: How to guarantee safe shipment?

Answer: We have shipping insurance. Our experienced team will do the customs documents, generally, it will have no trouble. And we will reship or refund for you if it is seized by our mistake.

 Question 4: How about delivery lead-time?

Answer: Shipping lead time: About 2-5 days after payment confirmed. (Chinese holiday not included), We have long-term relations with shipping agents in main Chinese ports. Full service can be offered, including photos of every shipment, marks, and procedure of loading. General times are gor 1KG-100KG, Within 5-7 days by DHL, UPS, TNT, FEDEX, EMS Over 100KG. within 5-8days by air, 20-40days by sea. More information.

Question 5: Is there a discount?

Answer: Different quantity has a different discount. Please feel free to contact us.

Question 6: How to contact us?

Answer: You can chat with us by Telegram, Email, Skype, Whatsapp, Facebook and other methods – just inquire, we will give a reply ASAP. Please feel free to send your quotations.

Question 7:How do you treat quality complaints?

Answer: Our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. We are competitive in API exporting, Pharmaceutical excipients,  food supplements, dyestuff, veterinary API. Our team has 20 years of experience in this business. Good team for quality control, shipping, and documents.

Question 8: Payment methods you accept?

U.S. funds preferably.

The negative impact of the production of pharmaceutical products on the natural environment is well known. However, this remains largely unregulated, meaning the extremely toxic impact it has on both animals and humans continues with no clear end in sight. As Ikigai Corporation Company Innovator, we are committed to expanding and improving our efforts to safeguard the environment. We accordingly established our environmental management system

Environmental management system
Quality Management, Environmental Management and Occupational Safety Policy

Quality Management, Environmental Management and Occupational Safety Policy
Ikigai Corporation Company is engaged in the production and distribution of pharmaceutical substances and other chemical specialties. As a chemical and pharmaceutical manufacturer, the Company is aware of the impacts of its activities on the product quality, on the environment and the health of its employees, and undertakes to control them, with the aim of constant improvement.

As standards for the implementation and maintenance of the Integrated Management System, the Company has chosen international standards ISO 9001 in the area of quality management (hereinafter called QMS), ISO 14001 for the management of environmental protection (hereinafter called EMS) and specification OHSAS 18000 for ensuring the occupational safety and health protection (hereinafter called SMS). The Integrated Management System applies to all fields of the Company’s activities.

Within this Policy, Ikigai Corporation Company undertakes to:

Constantly improve all of its activities
Executive commitment to continually improve energy efficiency across the entire corporation, including clear processes and tracking systems to identify opportunities
An empowered corporate energy director and energy team supported by sufficient human and financial resources
A corporate energy policy that is accounted for at the top levels of the corporation
Aggressive, numeric energy goals that stretch performance targets to draw out creative innovations for meeting them
Measurement and tracking of energy performance for all energy use, corporationwide, including benchmarking facility performance nationally and globally with similar companies, and a review system with accountability at all levels
Communication of the value of energy savings, importance of improving use of energy and executive commitment by consistently recognizing accomplishments.
Abide by the relevant legislation and other regulations which apply to the Company or which the Company has committed to observe; especially the requirements arisen from the Act on Pharmaceuticals, the Decree on Good Manufacturing Practice and other guidelines and directives and other requirements related to the occupational safety and the environmental protection.
Constantly educate and train its employees and strongly encourage them to improve the production quality, protect the environment and observe the occupational safety principles; to design the training so as to motivate the employees performing their jobs to prevent or reduce negative impacts of all activities on the environment.
Develop communication and cooperation with the public administration bodies, professional public and other parties concerned with the environmental protection issues. Ikigai Corporation Company is interested in holding open dialogue with the employees and the public, in informing both internal and external stakeholders of the impacts of all the Company’s activities on the environment and in responding to justified suggestions and concerns.
The executive management expects that all the Company employees will accept an opinion that observing the above mentioned principles and objectives is one of the most fundamental duties of every employee in the Company.



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