Pharmaceutical excipients

557-04-0.gif

Magnesium stearate is a white, water-insoluble powder. Its applications exploit its softness, insolubility in many solvents, and low toxicity. It is used as a release agent and as a component or lubricant in the production of pharmaceuticals and cosmetics.Some nutritional supplements specify that the sodium stearate used in manufacturing magnesium stearate is produced from vegetable-derived stearic acid.Magnesium stearate is often used as an anti-adherent in the manufacture of medical tablets, capsules and powders.Magnesium stearate can also be used efficiently in dry coating processes.In the creation of pressed candies, magnesium stearate acts as a release agent and it is used to bind sugar in hard candies such as mints.
Magnesium stearate is a common ingredient in baby formulas.

Application: For R&D Purpose.
WARNING! This product is not for human or veterinary use.
Need larger quantities for your development, manufacturing or research applications? Contact us.

CONTACT US

  • Overview
  • Product Description
  • Safety
  • Packaging & Delivery
  • Shipping & Payment FAQ
  • Environmental
Technical Information

Synonyms: stearatedemagnesium ;MAGNESIUM STEARATE;MAGNESIUM OCTADECANOATE;MAGENSIUM STEARATE;STEARIC ACID MAGNESIUM SALT;OCTADECONIC ACID MAGNESIUM SALT;OCTADECANOIC ACID MAGNESIUM SALT;Magnesium Stearate Bp
CAS No: 557-04-0
Molecular formula: 2(C18H35O2).Mg
Molecular weight: 591.25
Purity: 99%
Appearance: White to Almost white powder to crystal
Melting point: 88 °C
Formulation: MAGNESIUM STEARATE /IS/ COMPD OF MAGNESIUM WITH MIXTURE OF SOLID ORG ACIDS OBTAINED FROM FATS, & CONSISTS CHIEFLY OF VARIABLE PROPORTIONS OF MAGNESIUM STEARATE & MAGNESIUM PALMITATE. IT CONTAINS EQUIVALENT OF 6.8-8.0% OF MAGNESIUM OXIDE (40.30).
SMILES: CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
InChi Key: HQKMJHAJHXVSDF-UHFFFAOYSA-L
Grade Standard: N/a
Brand name: Ikigai ™
Standard: N/a

Shipping & Storage Information

Storage: Magnesium stearate is stable and should be stored in a well-closed container in a cool, dry place. Incompatible with strong acids, alkalis, and iron salts. Avoid mixing with strong oxidizing materials. Magnesium stearate cannot be used in products containing aspirin, some vitamins, and most alkaloidal salts.

Shipping: N/a
Stability (shelf life): ≥ 3 years
Origin: PRC

Pharmacology

N/A

Bionecessity

N/A

Mechanism of Action

Magnesium stearate is an additive that’s primarily used in medication capsules. It’s considered a “flow agent.” It prevents the individual ingredients in a capsule from sticking to each other and the machine that creates the capsules. It helps improve the consistency and quality control of medication capsules.

Overview

Magnesium stearate (Mg(C18H3502)2 or octadecanoic acid) is a solid, white powder at room temperature. It is a FDA-approved inactive ingredient commonly used in the pharmaceutical industry as a diluent for the manufacture of tablet, capsule, and powder dosage forms.

Use Classification

EPA Safer Chemical Functional Use Classes
Surfactants
Safer Chemical Classes
Green half-circle Green half-circle – The chemical is expected to be of low concern
JECFA Functional Classes
Food Additives: ANTICAKING_AGENT; EMULSIFIER

Uses

EPA CPDat Chemical and Product Categories

Category Category Description Categorization Type
Absorbent Agent for soaking up liquid (product use or application unknown) CPCat Cassette
Adhesive General adhesives and binding agents for a variety of uses CPCat Cassette
Adsorbent Adhesion of molecules to a surface CPCat Cassette
Agricultural Relating to agricultural, including the raising and farming of animals and growing of crops CPCat Cassette
Agricultural, animal Related to animals (but non-veterinary) e.g., animal husbandry, farming of animals/animal production, raising of animals for food or fur, animal feed, products for household pets CPCat Cassette
General Manufacturing Information
Industry Processing Sectors

All other chemical product and preparation manufacturing

Custom compounding of purchased resin

Food, beverage, and tobacco product manufacturing

Intercompany Shipments

Miscellaneous manufacturing

Petroleum lubricating oil and grease manufacturing

Pharmaceutical and medicine manufacturing

Plastic material and resin manufacturing

Plastics product manufacturing

Rubber product manufacturing

Textiles, apparel, and leather manufacturing

GHS Classification
Pictogram(s)
Irritant
Signal
Warning
GHS Hazard Statements Aggregated GHS information provided by 524 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 238 of 524 companies. For more detailed information, please visit ECHA C&L website

Of the 17 notification(s) provided by 286 of 524 companies with hazard statement code(s):

H315 (39.16%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (45.45%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (39.86%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H413 (52.8%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501

(The corresponding statement to each P-code can be found at the GHS Classification page.)

Accidental Release Measures

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Regulatory Information

FDA Requirements
An ingredient whose use in food or food packaging is subject to a prior sanction or approval within the meaning of section 201(s)(4) of the Act is exempt from classification as a food additive. … Substances classified as stabilizers, when migrating from food-packaging material shall include: magnesium stearate.

Non-Human Toxicity Values

N/A

Environmental Fate/Exposure Summary

Androstenedione’s production and administration as a drug to treat symptoms due to male andropause, dietary supplement, and athletic performance-enhancing drug may result in its release to the environment through various waste streams. Androstenedione is a naturally occurring androgen produced by the adrenal gland and converted to testosterone or estrone. It is produced naturally in humans during the production of testosterone and estrogen. It can be formed in soils via the metabolism of testosterone and estradiol occurring in poultry and livestock manures used as agricultural fertilizers. If released to air an extrapolated vapor pressure of 7.35X10-9 mm Hg at 20 °C indicates androstenedione will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase androstenedione will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and with ozone; the half-lives for these reactions in the air are estimated to be 3.5 hours and 1 day respectively. Particulate-phase androstenedione will be removed from the atmosphere by wet and dry deposition. Androstenedione absorbs light at wavelengths >290 nm, and therefore, may be susceptible to direct photolysis. If released to soil, androstenedione is expected to have no mobility based upon a Koc of 6170. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry’s Law constant of 3.7X10-8 atm-cu m/mole. Androstenedione is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Results of soil column studies using various soils and sands found that half-life of androstenedione ranged from 1.7 to 77 hours. If released into water, androstenedione is expected to adsorb to suspended solids and sediment based upon the Koc. Using OECD Guideline 301B (CO2 Evolution Test), androstenedione reached 79-95% degradation over a 28-day incubation period which classified the compound as readily biodegradable. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Androstenedione in aqueous solutions underwent direct photolysis half-lives ranging from 3.7 to 10.8 hours in direct sunlight. Occupational exposure to androstenedione may occur through dermal contact with this compound at workplaces where androstenedione is produced or used.

Supply Ability:

2000 Metric Ton/Metric Tons per Month

Packaging & Delivery

Packing: Export worthy packing (1kg/Aluminium foil bag;25kg/drum) Or as per customers request.
Ports: port of Hong Kong HKSAR of PRC.,  port of Ningbo, PRC or Any port in China.
Delivery methods:

By couriers:

Question 1: How to start orders for API materials?

Answer: Pro-forma invoice will be sent first after confirmation of the order, enclosed our payment information. Payment by T/T, Paypal, and others. All courier tracking numbers are provided upon shipping.

Question 2: What’s your MOQ?

Answer: The MOQ for this API is 1kg.

Question 3: How to guarantee safe shipment?

Answer: We have shipping insurance. Our experienced team will do the customs documents, generally, it will have no trouble. And we will reship or refund for you if it is seized by our mistake.

 Question 4: How about delivery lead-time?

Answer: Shipping lead time: About 2-5 days after payment confirmed. (Chinese holiday not included), We have long-term relations with shipping agents in main Chinese ports. Full service can be offered, including photos of every shipment, marks, and procedure of loading. General times are gor 1KG-100KG, Within 5-7 days by DHL, UPS, TNT, FEDEX, EMS Over 100KG. within 5-8days by air, 20-40days by sea. More information.

Question 5: Is there a discount?

Answer: Different quantity has a different discount. Please feel free to contact us.

Question 6: How to contact us?

Answer: You can chat with us by Telegram, Email, Skype, Whatsapp, Facebook and other methods – just inquire, we will give a reply ASAP. Please feel free to send your quotations.

Question 7:How do you treat quality complaints?

Answer: Our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. We are competitive in API exporting, Pharmaceutical excipients,  food supplements, dyestuff, veterinary API. Our team has 20 years of experience in this business. Good team for quality control, shipping, and documents.

Question 8: Payment methods you accept?

U.S. funds preferably.

The negative impact of the production of pharmaceutical products on the natural environment is well known. However, this remains largely unregulated, meaning the extremely toxic impact it has on both animals and humans continues with no clear end in sight. As Ikigai Corporation Company Innovator, we are committed to expanding and improving our efforts to safeguard the environment. We accordingly established our environmental management system

Environmental management system
Quality Management, Environmental Management and Occupational Safety Policy

Quality Management, Environmental Management and Occupational Safety Policy
Ikigai Corporation Company is engaged in the production and distribution of pharmaceutical substances and other chemical specialties. As a chemical and pharmaceutical manufacturer, the Company is aware of the impacts of its activities on the product quality, on the environment and the health of its employees, and undertakes to control them, with the aim of constant improvement.

As standards for the implementation and maintenance of the Integrated Management System, the Company has chosen international standards ISO 9001 in the area of quality management (hereinafter called QMS), ISO 14001 for the management of environmental protection (hereinafter called EMS) and specification OHSAS 18000 for ensuring the occupational safety and health protection (hereinafter called SMS). The Integrated Management System applies to all fields of the Company’s activities.

Within this Policy, Ikigai Corporation Company undertakes to:

Constantly improve all of its activities
Executive commitment to continually improve energy efficiency across the entire corporation, including clear processes and tracking systems to identify opportunities
An empowered corporate energy director and energy team supported by sufficient human and financial resources
A corporate energy policy that is accounted for at the top levels of the corporation
Aggressive, numeric energy goals that stretch performance targets to draw out creative innovations for meeting them
Measurement and tracking of energy performance for all energy use, corporationwide, including benchmarking facility performance nationally and globally with similar companies, and a review system with accountability at all levels
Communication of the value of energy savings, importance of improving use of energy and executive commitment by consistently recognizing accomplishments.
Abide by the relevant legislation and other regulations which apply to the Company or which the Company has committed to observe; especially the requirements arisen from the Act on Pharmaceuticals, the Decree on Good Manufacturing Practice and other guidelines and directives and other requirements related to the occupational safety and the environmental protection.
Constantly educate and train its employees and strongly encourage them to improve the production quality, protect the environment and observe the occupational safety principles; to design the training so as to motivate the employees performing their jobs to prevent or reduce negative impacts of all activities on the environment.
Develop communication and cooperation with the public administration bodies, professional public and other parties concerned with the environmental protection issues. Ikigai Corporation Company is interested in holding open dialogue with the employees and the public, in informing both internal and external stakeholders of the impacts of all the Company’s activities on the environment and in responding to justified suggestions and concerns.
The executive management expects that all the Company employees will accept an opinion that observing the above mentioned principles and objectives is one of the most fundamental duties of every employee in the Company.



557-05-1.png

Zinc stearate is a “zinc soap” that is widely used industrially. In this context, soap is used in its formal sense, a metal “salt” of a fatty acid. It is a white solid that repels water. It is insoluble in polar solvents such as alcohol and ether but soluble in aromatic hydrocarbons (e.g., benzene) and chlorinated hydrocarbons when heated. It is the most powerful mold release agent among all metal soaps. It contains no electrolyte and has a hydrophobic effect. Its main application areas are the plastics and rubber industry, where it is used as a releasing agent and lubricant which can be easily incorporated.


CONTACT US

  • Overview
  • Product Description
  • Safety
  • Packaging & Delivery
  • Shipping & Payment FAQ
  • Environmental
Technical Information

Synonyms: Afco-chem ZNS;ai3-00388 ;Antidust 2;caswellno926 ;Coad;Dermarone;Dibasic zinc stearate;dibasiczincstearate
CAS No: 557-05-1 (8028-87-3)
Molecular formula: C36H70O4Zn or Zn(C18H35O2)2
Molecular weight: 632.3 g/mol
Purity: N/A
Appearance: Soft, white powder
Melting point: 130 °C
Formulation: Zinc stearate USP; 60 g and 125 g shaker containers.
SMILES: CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Zn+2]
InChi Key: AEMFNILZOJDQLW-QAGGRKNESA-N
Grade Standard: N/A
Brand name: Ikigai ™
Standard: USP, Ph. Eur., JP Etc

Shipping & Storage Information

Storage: Zinc stearate is stable and should be stored in a cool, dry place
Shipping: N/A
Stability (shelf life): ≥ 1 year
Origin: PRC

Uses
Category Category Description Categorization Type
Absorbent Agent for soaking up liquid (product use or application unknown) CPCat Cassette
Adhesive General adhesives and binding agents for a variety of uses CPCat Cassette
Adsorbent Adhesion of molecules to a surface CPCat Cassette
Antiadhesive Used to prevent adhesion CPCat Cassette
Antifriction Additives to reduce friction CPCat Cassette
General Manufacturing Information

GHS Classification
Pictogram(s)
Irritant
Environmental Hazard
Signal
Warning
GHS Hazard Statements Aggregated GHS information provided by 1973 companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 1179 of 1973 companies. For more detailed information, please visit ECHA C&L website

Of the 20 notification(s) provided by 794 of 1973 companies with hazard statement code(s):

H335 (75.31%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H400 (81.99%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H413 (59.82%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes P261, P271, P273, P304+P340, P312, P391, P403+P233, P405, and P501

(The corresponding statement to each P-code can be found at the GHS Classification page.)

Accidental Release Measures

Disposal Methods
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Regulatory Information

FDA Requirements
The substances listed in paragraph (b) of this section may be safely used as antioxidants and/or stabilizers in polymers used in the manufacture of articles or components of articles intended for use in producing, manufacturing, packing, processing, preparing, treating, packaging, transporting, or holding food, subject to the provisions of this section: (a) The quantity used shall not exceed the amount reasonably required to accomplish the intended technical effect. Zinc stearate is included on this list.

Non-Human Toxicity Values

LD50 Rat ip 0.25 g/kg /SRP: 250mg/kg/
LD50 Rat oral >5000 mg/kg
LC50 Rat Inhalation >200 mg/L (1 hr)
LD50 Rabbit dermal >2000 mg/kg

Environmental Fate/Exposure Summary

Androstenedione’s production and administration as a drug to treat symptoms due to male andropause, dietary supplement, and athletic performance-enhancing drug may result in its release to the environment through various waste streams. Androstenedione is a naturally occurring androgen produced by the adrenal gland and converted to testosterone or estrone. It is produced naturally in humans during the production of testosterone and estrogen. It can be formed in soils via the metabolism of testosterone and estradiol occurring in poultry and livestock manures used as agricultural fertilizers. If released to air an extrapolated vapor pressure of 7.35X10-9 mm Hg at 20 °C indicates androstenedione will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase androstenedione will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and with ozone; the half-lives for these reactions in the air are estimated to be 3.5 hours and 1 day respectively. Particulate-phase androstenedione will be removed from the atmosphere by wet and dry deposition. Androstenedione absorbs light at wavelengths >290 nm, and therefore, may be susceptible to direct photolysis. If released to soil, androstenedione is expected to have no mobility based upon a Koc of 6170. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry’s Law constant of 3.7X10-8 atm-cu m/mole. Androstenedione is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Results of soil column studies using various soils and sands found that half-life of androstenedione ranged from 1.7 to 77 hours. If released into water, androstenedione is expected to adsorb to suspended solids and sediment based upon the Koc. Using OECD Guideline 301B (CO2 Evolution Test), androstenedione reached 79-95% degradation over a 28-day incubation period which classified the compound as readily biodegradable. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Androstenedione in aqueous solutions underwent direct photolysis half-lives ranging from 3.7 to 10.8 hours in direct sunlight. Occupational exposure to androstenedione may occur through dermal contact with this compound at workplaces where androstenedione is produced or used.

Supply Ability:

2000 Metric Ton/Metric Tons per Month

Packaging & Delivery

Packing: Export worthy packing (1kg/Aluminium foil bag;25kg/drum) Or as per customers request.
Ports: port of Hong Kong HKSAR of PRC.,  port of Ningbo, PRC or Any port in China.
Delivery methods:

By couriers:

Question 1: How to start orders for API materials?

Answer: Pro-forma invoice will be sent first after confirmation of the order, enclosed our payment information. Payment by T/T, Paypal, and others. All courier tracking numbers are provided upon shipping.

Question 2: What’s your MOQ?

Answer: The MOQ for this API is 1kg.

Question 3: How to guarantee safe shipment?

Answer: We have shipping insurance. Our experienced team will do the customs documents, generally, it will have no trouble. And we will reship or refund for you if it is seized by our mistake.

 Question 4: How about delivery lead-time?

Answer: Shipping lead time: About 2-5 days after payment confirmed. (Chinese holiday not included), We have long-term relations with shipping agents in main Chinese ports. Full service can be offered, including photos of every shipment, marks, and procedure of loading. General times are gor 1KG-100KG, Within 5-7 days by DHL, UPS, TNT, FEDEX, EMS Over 100KG. within 5-8days by air, 20-40days by sea. More information.

Question 5: Is there a discount?

Answer: Different quantity has a different discount. Please feel free to contact us.

Question 6: How to contact us?

Answer: You can chat with us by Telegram, Email, Skype, Whatsapp, Facebook and other methods – just inquire, we will give a reply ASAP. Please feel free to send your quotations.

Question 7:How do you treat quality complaints?

Answer: Our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. We are competitive in API exporting, Pharmaceutical excipients,  food supplements, dyestuff, veterinary API. Our team has 20 years of experience in this business. Good team for quality control, shipping, and documents.

Question 8: Payment methods you accept?

U.S. funds preferably.

The negative impact of the production of pharmaceutical products on the natural environment is well known. However, this remains largely unregulated, meaning the extremely toxic impact it has on both animals and humans continues with no clear end in sight. As Ikigai Corporation Company Innovator, we are committed to expanding and improving our efforts to safeguard the environment. We accordingly established our environmental management system

Environmental management system
Quality Management, Environmental Management and Occupational Safety Policy

Quality Management, Environmental Management and Occupational Safety Policy
Ikigai Corporation Company is engaged in the production and distribution of pharmaceutical substances and other chemical specialties. As a chemical and pharmaceutical manufacturer, the Company is aware of the impacts of its activities on the product quality, on the environment and the health of its employees, and undertakes to control them, with the aim of constant improvement.

As standards for the implementation and maintenance of the Integrated Management System, the Company has chosen international standards ISO 9001 in the area of quality management (hereinafter called QMS), ISO 14001 for the management of environmental protection (hereinafter called EMS) and specification OHSAS 18000 for ensuring the occupational safety and health protection (hereinafter called SMS). The Integrated Management System applies to all fields of the Company’s activities.

Within this Policy, Ikigai Corporation Company undertakes to:

Constantly improve all of its activities
Executive commitment to continually improve energy efficiency across the entire corporation, including clear processes and tracking systems to identify opportunities
An empowered corporate energy director and energy team supported by sufficient human and financial resources
A corporate energy policy that is accounted for at the top levels of the corporation
Aggressive, numeric energy goals that stretch performance targets to draw out creative innovations for meeting them
Measurement and tracking of energy performance for all energy use, corporationwide, including benchmarking facility performance nationally and globally with similar companies, and a review system with accountability at all levels
Communication of the value of energy savings, importance of improving use of energy and executive commitment by consistently recognizing accomplishments.
Abide by the relevant legislation and other regulations which apply to the Company or which the Company has committed to observe; especially the requirements arisen from the Act on Pharmaceuticals, the Decree on Good Manufacturing Practice and other guidelines and directives and other requirements related to the occupational safety and the environmental protection.
Constantly educate and train its employees and strongly encourage them to improve the production quality, protect the environment and observe the occupational safety principles; to design the training so as to motivate the employees performing their jobs to prevent or reduce negative impacts of all activities on the environment.
Develop communication and cooperation with the public administration bodies, professional public and other parties concerned with the environmental protection issues. Ikigai Corporation Company is interested in holding open dialogue with the employees and the public, in informing both internal and external stakeholders of the impacts of all the Company’s activities on the environment and in responding to justified suggestions and concerns.
The executive management expects that all the Company employees will accept an opinion that observing the above mentioned principles and objectives is one of the most fundamental duties of every employee in the Company.



9063-38-1.jpg

Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. It is used as a disintegrant, a suspending agent and as a gelling agent.


CONTACT US

  • Overview
  • Product Description
  • Safety
  • Packaging & Delivery
  • Shipping & Payment FAQ
  • Environmental
Technical Information

Synonyms: sodium carboxyl methylstarch;SODIUM STARCH GLYCOLATE;SODIUM STARCH GLYCOLLATE;PRIMOJEL(R);CARBOXYMETHYL STARCH SODIUM;CARBOXYMETHYL STARCH SODIUM SALT;CMS-Na ;explotab
CAS No: 9063-38-1
Molecular formula: C10H19NaO8
Molecular weight: 515.6862
Purity: N/A
Appearance: N/A
Melting point: Chars At About 200 ° C
Formulation: N/A
SMILES: N/A
InChi Key: MOSFIJXAXDLOML-UHFFFAOYSA-N
Grade Standard: N/A
Brand name: Ikigai ™
Standard: USP, Ph. Eur., JP Etc

Shipping & Storage Information

Storage: -20°C
Shipping: Room Temperature (may vary elsewhere)
Stability (shelf life): ≥ 3 years
Origin: PRC

Uses

N/A

General Manufacturing Information

GHS Classification

This chemical is considered hazardous according to the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)
Considered a dangerous substance or mixture according to the Globally Harmonized System (GHS)

Accidental Release Measures

Personal precautions, protective equipment and emergency procedures
Personal Precautions: Ensure adequate ventilation. Use personal protective equipment. Avoid contact with skin, eyes and clothing. Remove all sources of ignition. Avoid dust formation. Avoid dispersal of
dust in the air. Dust deposits should not be allowed to accumulate on surfaces, as these
may form an explosive mixture if they are released into the atmosphere in sufficient
concentration. Non-sparking tools should be used. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not flush into surface water
or sanitary sewer system.
Methods and material for containment and cleaning up
Methods for containment Stop leak if you can do it without risk. Cover with plastic sheet to prevent
spreading.
Methods for cleaning up Sweep up and shovel into suitable containers for disposal. Avoid creating dust. Use only non-sparking tools. Clean contaminated surface thoroughly.

Regulatory Information

FDA Requirements
N/A

Non-Human Toxicity Values

N/A

Environmental Fate/Exposure Summary

Androstenedione’s production and administration as a drug to treat symptoms due to male andropause, dietary supplement, and athletic performance-enhancing drug may result in its release to the environment through various waste streams. Androstenedione is a naturally occurring androgen produced by the adrenal gland and converted to testosterone or estrone. It is produced naturally in humans during the production of testosterone and estrogen. It can be formed in soils via the metabolism of testosterone and estradiol occurring in poultry and livestock manures used as agricultural fertilizers. If released to air an extrapolated vapor pressure of 7.35X10-9 mm Hg at 20 °C indicates androstenedione will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase androstenedione will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and with ozone; the half-lives for these reactions in the air are estimated to be 3.5 hours and 1 day respectively. Particulate-phase androstenedione will be removed from the atmosphere by wet and dry deposition. Androstenedione absorbs light at wavelengths >290 nm, and therefore, may be susceptible to direct photolysis. If released to soil, androstenedione is expected to have no mobility based upon a Koc of 6170. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry’s Law constant of 3.7X10-8 atm-cu m/mole. Androstenedione is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Results of soil column studies using various soils and sands found that half-life of androstenedione ranged from 1.7 to 77 hours. If released into water, androstenedione is expected to adsorb to suspended solids and sediment based upon the Koc. Using OECD Guideline 301B (CO2 Evolution Test), androstenedione reached 79-95% degradation over a 28-day incubation period which classified the compound as readily biodegradable. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Androstenedione in aqueous solutions underwent direct photolysis half-lives ranging from 3.7 to 10.8 hours in direct sunlight. Occupational exposure to androstenedione may occur through dermal contact with this compound at workplaces where androstenedione is produced or used.

Supply Ability:

2000 Metric Ton/Metric Tons per Month

Packaging & Delivery

Packing: Export worthy packing (1kg/Aluminium foil bag;25kg/drum) Or as per customers request.
Ports: port of Hong Kong HKSAR of PRC.,  port of Ningbo, PRC or Any port in China.
Delivery methods:

By couriers:

Question 1: How to start orders for API materials?

Answer: Pro-forma invoice will be sent first after confirmation of the order, enclosed our payment information. Payment by T/T, Paypal, and others. All courier tracking numbers are provided upon shipping.

Question 2: What’s your MOQ?

Answer: The MOQ for this API is 1kg.

Question 3: How to guarantee safe shipment?

Answer: We have shipping insurance. Our experienced team will do the customs documents, generally, it will have no trouble. And we will reship or refund for you if it is seized by our mistake.

 Question 4: How about delivery lead-time?

Answer: Shipping lead time: About 2-5 days after payment confirmed. (Chinese holiday not included), We have long-term relations with shipping agents in main Chinese ports. Full service can be offered, including photos of every shipment, marks, and procedure of loading. General times are gor 1KG-100KG, Within 5-7 days by DHL, UPS, TNT, FEDEX, EMS Over 100KG. within 5-8days by air, 20-40days by sea. More information.

Question 5: Is there a discount?

Answer: Different quantity has a different discount. Please feel free to contact us.

Question 6: How to contact us?

Answer: You can chat with us by Telegram, Email, Skype, Whatsapp, Facebook and other methods – just inquire, we will give a reply ASAP. Please feel free to send your quotations.

Question 7:How do you treat quality complaints?

Answer: Our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. We are competitive in API exporting, Pharmaceutical excipients,  food supplements, dyestuff, veterinary API. Our team has 20 years of experience in this business. Good team for quality control, shipping, and documents.

Question 8: Payment methods you accept?

U.S. funds preferably.

The negative impact of the production of pharmaceutical products on the natural environment is well known. However, this remains largely unregulated, meaning the extremely toxic impact it has on both animals and humans continues with no clear end in sight. As Ikigai Corporation Company Innovator, we are committed to expanding and improving our efforts to safeguard the environment. We accordingly established our environmental management system

Environmental management system
Quality Management, Environmental Management and Occupational Safety Policy

Quality Management, Environmental Management and Occupational Safety Policy
Ikigai Corporation Company is engaged in the production and distribution of pharmaceutical substances and other chemical specialties. As a chemical and pharmaceutical manufacturer, the Company is aware of the impacts of its activities on the product quality, on the environment and the health of its employees, and undertakes to control them, with the aim of constant improvement.

As standards for the implementation and maintenance of the Integrated Management System, the Company has chosen international standards ISO 9001 in the area of quality management (hereinafter called QMS), ISO 14001 for the management of environmental protection (hereinafter called EMS) and specification OHSAS 18000 for ensuring the occupational safety and health protection (hereinafter called SMS). The Integrated Management System applies to all fields of the Company’s activities.

Within this Policy, Ikigai Corporation Company undertakes to:

Constantly improve all of its activities
Executive commitment to continually improve energy efficiency across the entire corporation, including clear processes and tracking systems to identify opportunities
An empowered corporate energy director and energy team supported by sufficient human and financial resources
A corporate energy policy that is accounted for at the top levels of the corporation
Aggressive, numeric energy goals that stretch performance targets to draw out creative innovations for meeting them
Measurement and tracking of energy performance for all energy use, corporationwide, including benchmarking facility performance nationally and globally with similar companies, and a review system with accountability at all levels
Communication of the value of energy savings, importance of improving use of energy and executive commitment by consistently recognizing accomplishments.
Abide by the relevant legislation and other regulations which apply to the Company or which the Company has committed to observe; especially the requirements arisen from the Act on Pharmaceuticals, the Decree on Good Manufacturing Practice and other guidelines and directives and other requirements related to the occupational safety and the environmental protection.
Constantly educate and train its employees and strongly encourage them to improve the production quality, protect the environment and observe the occupational safety principles; to design the training so as to motivate the employees performing their jobs to prevent or reduce negative impacts of all activities on the environment.
Develop communication and cooperation with the public administration bodies, professional public and other parties concerned with the environmental protection issues. Ikigai Corporation Company is interested in holding open dialogue with the employees and the public, in informing both internal and external stakeholders of the impacts of all the Company’s activities on the environment and in responding to justified suggestions and concerns.
The executive management expects that all the Company employees will accept an opinion that observing the above mentioned principles and objectives is one of the most fundamental duties of every employee in the Company.



9004-34-6.png

Microcrystalline cellulose (MCC) is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. The most common form is used in vitamin supplements or tablets. It is also used in plaque assays for counting viruses, as an alternative to carboxymethylcellulose.


CONTACT US

  • Overview
  • Product Description
  • Safety
  • Packaging & Delivery
  • Shipping & Payment FAQ
  • Environmental
Technical Information

Synonyms:AVICEL PH;AVICEL PH 101(R);AVICEL PH 102;AVICEL PH 105(R);AVICEL(R);”AVICEL(R)”;AVICEL SF;AVIRIN
CAS No: 9004-34-6
Molecular formula: (C6H10O5)n or C12H22O11
Molecular weight: 342.3 g/mol
Purity: 99%
Appearance: white powder
Melting point: 500 to 518 °F (Decomposes) (NIOSH, 2016)
Formulation: A neat solid
SMILES: C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)O)CO)O)O)O)O
InChi Key: GUBGYTABKSRVRQ-WFVLMXAXSA-N
Grade Standard: N/A
Brand name: Ikigai ™
Standard: USP, Ph. Eur., JP Etc

Shipping & Storage Information

Storage: Store in a cool, dry place
Shipping: N/A
Stability (shelf life): ≥ Stable
Origin: PRC

Uses

Use Classification
Food additives

General Manufacturing Information

EPA TSCA Commercial Activity Status
Cellulose: ACTIVE

EPA Chemicals under the TSCA
EPA TSCA Regulatory Flag
XU – indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).

EPA Chemicals under the TSCA

GHS Classification
GHS Hazard Statements Not Classified

Reported as not meeting GHS hazard criteria by 3047 of 3107 companies (only ~ 1.9% companies provided GHS information). For more detailed information, please visit ECHA C&L website

Accidental Release Measures

Disposal Methods
N/A

Regulatory Information

FDA Requirements
N/A

Non-Human Toxicity Values

N/A

Environmental Fate/Exposure Summary

Androstenedione’s production and administration as a drug to treat symptoms due to male andropause, dietary supplement, and athletic performance-enhancing drug may result in its release to the environment through various waste streams. Androstenedione is a naturally occurring androgen produced by the adrenal gland and converted to testosterone or estrone. It is produced naturally in humans during the production of testosterone and estrogen. It can be formed in soils via the metabolism of testosterone and estradiol occurring in poultry and livestock manures used as agricultural fertilizers. If released to air an extrapolated vapor pressure of 7.35X10-9 mm Hg at 20 °C indicates androstenedione will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase androstenedione will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and with ozone; the half-lives for these reactions in the air are estimated to be 3.5 hours and 1 day respectively. Particulate-phase androstenedione will be removed from the atmosphere by wet and dry deposition. Androstenedione absorbs light at wavelengths >290 nm, and therefore, may be susceptible to direct photolysis. If released to soil, androstenedione is expected to have no mobility based upon a Koc of 6170. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry’s Law constant of 3.7X10-8 atm-cu m/mole. Androstenedione is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Results of soil column studies using various soils and sands found that half-life of androstenedione ranged from 1.7 to 77 hours. If released into water, androstenedione is expected to adsorb to suspended solids and sediment based upon the Koc. Using OECD Guideline 301B (CO2 Evolution Test), androstenedione reached 79-95% degradation over a 28-day incubation period which classified the compound as readily biodegradable. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Androstenedione in aqueous solutions underwent direct photolysis half-lives ranging from 3.7 to 10.8 hours in direct sunlight. Occupational exposure to androstenedione may occur through dermal contact with this compound at workplaces where androstenedione is produced or used.

Supply Ability:

2000 Metric Ton/Metric Tons per Month

Packaging & Delivery

Packing: Export worthy packing (1kg/Aluminium foil bag;25kg/drum) Or as per customers request.
Ports: port of Hong Kong HKSAR of PRC.,  port of Ningbo, PRC or Any port in China.
Delivery methods:

By couriers:

Question 1: How to start orders for API materials?

Answer: Pro-forma invoice will be sent first after confirmation of the order, enclosed our payment information. Payment by T/T, Paypal, and others. All courier tracking numbers are provided upon shipping.

Question 2: What’s your MOQ?

Answer: The MOQ for this API is 1kg.

Question 3: How to guarantee safe shipment?

Answer: We have shipping insurance. Our experienced team will do the customs documents, generally, it will have no trouble. And we will reship or refund for you if it is seized by our mistake.

 Question 4: How about delivery lead-time?

Answer: Shipping lead time: About 2-5 days after payment confirmed. (Chinese holiday not included), We have long-term relations with shipping agents in main Chinese ports. Full service can be offered, including photos of every shipment, marks, and procedure of loading. General times are gor 1KG-100KG, Within 5-7 days by DHL, UPS, TNT, FEDEX, EMS Over 100KG. within 5-8days by air, 20-40days by sea. More information.

Question 5: Is there a discount?

Answer: Different quantity has a different discount. Please feel free to contact us.

Question 6: How to contact us?

Answer: You can chat with us by Telegram, Email, Skype, Whatsapp, Facebook and other methods – just inquire, we will give a reply ASAP. Please feel free to send your quotations.

Question 7:How do you treat quality complaints?

Answer: Our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. We are competitive in API exporting, Pharmaceutical excipients,  food supplements, dyestuff, veterinary API. Our team has 20 years of experience in this business. Good team for quality control, shipping, and documents.

Question 8: Payment methods you accept?

U.S. funds preferably.

The negative impact of the production of pharmaceutical products on the natural environment is well known. However, this remains largely unregulated, meaning the extremely toxic impact it has on both animals and humans continues with no clear end in sight. As Ikigai Corporation Company Innovator, we are committed to expanding and improving our efforts to safeguard the environment. We accordingly established our environmental management system

Environmental management system
Quality Management, Environmental Management and Occupational Safety Policy

Quality Management, Environmental Management and Occupational Safety Policy
Ikigai Corporation Company is engaged in the production and distribution of pharmaceutical substances and other chemical specialties. As a chemical and pharmaceutical manufacturer, the Company is aware of the impacts of its activities on the product quality, on the environment and the health of its employees, and undertakes to control them, with the aim of constant improvement.

As standards for the implementation and maintenance of the Integrated Management System, the Company has chosen international standards ISO 9001 in the area of quality management (hereinafter called QMS), ISO 14001 for the management of environmental protection (hereinafter called EMS) and specification OHSAS 18000 for ensuring the occupational safety and health protection (hereinafter called SMS). The Integrated Management System applies to all fields of the Company’s activities.

Within this Policy, Ikigai Corporation Company undertakes to:

Constantly improve all of its activities
Executive commitment to continually improve energy efficiency across the entire corporation, including clear processes and tracking systems to identify opportunities
An empowered corporate energy director and energy team supported by sufficient human and financial resources
A corporate energy policy that is accounted for at the top levels of the corporation
Aggressive, numeric energy goals that stretch performance targets to draw out creative innovations for meeting them
Measurement and tracking of energy performance for all energy use, corporationwide, including benchmarking facility performance nationally and globally with similar companies, and a review system with accountability at all levels
Communication of the value of energy savings, importance of improving use of energy and executive commitment by consistently recognizing accomplishments.
Abide by the relevant legislation and other regulations which apply to the Company or which the Company has committed to observe; especially the requirements arisen from the Act on Pharmaceuticals, the Decree on Good Manufacturing Practice and other guidelines and directives and other requirements related to the occupational safety and the environmental protection.
Constantly educate and train its employees and strongly encourage them to improve the production quality, protect the environment and observe the occupational safety principles; to design the training so as to motivate the employees performing their jobs to prevent or reduce negative impacts of all activities on the environment.
Develop communication and cooperation with the public administration bodies, professional public and other parties concerned with the environmental protection issues. Ikigai Corporation Company is interested in holding open dialogue with the employees and the public, in informing both internal and external stakeholders of the impacts of all the Company’s activities on the environment and in responding to justified suggestions and concerns.
The executive management expects that all the Company employees will accept an opinion that observing the above mentioned principles and objectives is one of the most fundamental duties of every employee in the Company.




Croscarmellose sodium, or sodium CMC, is a cross-linked polymer of carboxymethylcellulose sodium. It appears as white, fibrous, free-flowing powder, and is used commonly as an FDA-approved disintegrant in pharmaceutical manufacturing. Disintegrants facilitate the breakup of a tablet in the intestinal tract after oral administration. Cross-linking allows enhanced bioavailability of the drug through superior drug dissolution. Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.


CONTACT US

  • Overview
  • Product Description
  • Safety
  • Packaging & Delivery
  • Shipping & Payment FAQ
  • Environmental
Technical Information

Synonyms:Sodiumcroscarmellose ;CROSCARMELLOSE SODIUM;MODIFIED CELLULOSE GUM;PRIMELLOSE(R);Crosscarmelosesodium;Croscarmellose natrium;Cross-linked carboxymethylcellulose sodium;Unii-m28ol1hh48
CAS No: 74811-65-7
Molecular formula: N/A
Molecular weight: N/A
Purity: N/A
Appearance: N/A
Melting point: N/A
Formulation: N/A
SMILES:N/A
InChi Key: N/A
Grade Standard:N/A
Brand name: Ikigai ™
Standard: USP, Ph. Eur., JP Etc

Shipping & Storage Information

Storage: N/A
Shipping: N/A
Stability (shelf life): N/A
Origin: PRC

Pharmacology

N/A

Bionecessity

N/A

Mechanism of Action

N/A

Overview

Sodium croscarmellose is an internally cross-linked sodium carboxymethylcellulose for use as a superdisintegrant in pharmaceutical formulations.
E468 is the E number of crosslinked sodium carboxymethyl cellulose, used in food as an emulsifier.

Use Classification

N/A

Uses

N/A

GHS Classification
Pictogram(s)
Irritant
Health Hazard
Signal
Danger
GHS Hazard Statements Aggregated GHS information provided by 47 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H302 (97.87%): Harmful if swallowed [Warning Acute toxicity, oral]

H351 (95.74%): Suspected of causing cancer [Warning Carcinogenicity]

H360 (95.74%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H362 (95.74%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes P201, P202, P260, P263, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501
Accidental Release Measures

Disposal Methods
SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state-licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Regulatory Information

FDA Requirements
Schedule III shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. Each drug or substance has been assigned the DEA Controlled Substances Code Number set forth opposite it. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture or preparation containing any quantity of the following substances, including its salts, esters, and ethers.

Non-Human Toxicity Values

LD50 Rat (male) oral between 500 and 1000 mg/kg BW
LD50 Rat (female) oral >500 mg/kg BW
LD50 Rat (male and female) dermal >2000 mg/kg BW

Environmental Fate/Exposure Summary

Androstenedione’s production and administration as a drug to treat symptoms due to male andropause, dietary supplement, and athletic performance-enhancing drug may result in its release to the environment through various waste streams. Androstenedione is a naturally occurring androgen produced by the adrenal gland and converted to testosterone or estrone. It is produced naturally in humans during the production of testosterone and estrogen. It can be formed in soils via the metabolism of testosterone and estradiol occurring in poultry and livestock manures used as agricultural fertilizers. If released to air an extrapolated vapor pressure of 7.35X10-9 mm Hg at 20 °C indicates androstenedione will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase androstenedione will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and with ozone; the half-lives for these reactions in the air are estimated to be 3.5 hours and 1 day respectively. Particulate-phase androstenedione will be removed from the atmosphere by wet and dry deposition. Androstenedione absorbs light at wavelengths >290 nm, and therefore, may be susceptible to direct photolysis. If released to soil, androstenedione is expected to have no mobility based upon a Koc of 6170. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry’s Law constant of 3.7X10-8 atm-cu m/mole. Androstenedione is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Results of soil column studies using various soils and sands found that half-life of androstenedione ranged from 1.7 to 77 hours. If released into water, androstenedione is expected to adsorb to suspended solids and sediment based upon the Koc. Using OECD Guideline 301B (CO2 Evolution Test), androstenedione reached 79-95% degradation over a 28-day incubation period which classified the compound as readily biodegradable. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Androstenedione in aqueous solutions underwent direct photolysis half-lives ranging from 3.7 to 10.8 hours in direct sunlight. Occupational exposure to androstenedione may occur through dermal contact with this compound at workplaces where androstenedione is produced or used.

Supply Ability:

2000 Metric Ton/Metric Tons per Month

Packaging & Delivery

Packing: Export worthy packing (1kg/Aluminium foil bag;25kg/drum) Or as per customers request.
Ports: port of Hong Kong HKSAR of PRC.,  port of Ningbo, PRC or Any port in China.
Delivery methods:

By couriers:

Question 1: How to start orders for API materials?

Answer: Pro-forma invoice will be sent first after confirmation of the order, enclosed our payment information. Payment by T/T, Paypal, and others. All courier tracking numbers are provided upon shipping.

Question 2: What’s your MOQ?

Answer: The MOQ for this API is 1kg.

Question 3: How to guarantee safe shipment?

Answer: We have shipping insurance. Our experienced team will do the customs documents, generally, it will have no trouble. And we will reship or refund for you if it is seized by our mistake.

 Question 4: How about delivery lead-time?

Answer: Shipping lead time: About 2-5 days after payment confirmed. (Chinese holiday not included), We have long-term relations with shipping agents in main Chinese ports. Full service can be offered, including photos of every shipment, marks, and procedure of loading. General times are gor 1KG-100KG, Within 5-7 days by DHL, UPS, TNT, FEDEX, EMS Over 100KG. within 5-8days by air, 20-40days by sea. More information.

Question 5: Is there a discount?

Answer: Different quantity has a different discount. Please feel free to contact us.

Question 6: How to contact us?

Answer: You can chat with us by Telegram, Email, Skype, Whatsapp, Facebook and other methods – just inquire, we will give a reply ASAP. Please feel free to send your quotations.

Question 7:How do you treat quality complaints?

Answer: Our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. We are competitive in API exporting, Pharmaceutical excipients,  food supplements, dyestuff, veterinary API. Our team has 20 years of experience in this business. Good team for quality control, shipping, and documents.

Question 8: Payment methods you accept?

U.S. funds preferably.

The negative impact of the production of pharmaceutical products on the natural environment is well known. However, this remains largely unregulated, meaning the extremely toxic impact it has on both animals and humans continues with no clear end in sight. As Ikigai Corporation Company Innovator, we are committed to expanding and improving our efforts to safeguard the environment. We accordingly established our environmental management system

Environmental management system
Quality Management, Environmental Management and Occupational Safety Policy

Quality Management, Environmental Management and Occupational Safety Policy
Ikigai Corporation Company is engaged in the production and distribution of pharmaceutical substances and other chemical specialties. As a chemical and pharmaceutical manufacturer, the Company is aware of the impacts of its activities on the product quality, on the environment and the health of its employees, and undertakes to control them, with the aim of constant improvement.

As standards for the implementation and maintenance of the Integrated Management System, the Company has chosen international standards ISO 9001 in the area of quality management (hereinafter called QMS), ISO 14001 for the management of environmental protection (hereinafter called EMS) and specification OHSAS 18000 for ensuring the occupational safety and health protection (hereinafter called SMS). The Integrated Management System applies to all fields of the Company’s activities.

Within this Policy, Ikigai Corporation Company undertakes to:

Constantly improve all of its activities
Executive commitment to continually improve energy efficiency across the entire corporation, including clear processes and tracking systems to identify opportunities
An empowered corporate energy director and energy team supported by sufficient human and financial resources
A corporate energy policy that is accounted for at the top levels of the corporation
Aggressive, numeric energy goals that stretch performance targets to draw out creative innovations for meeting them
Measurement and tracking of energy performance for all energy use, corporationwide, including benchmarking facility performance nationally and globally with similar companies, and a review system with accountability at all levels
Communication of the value of energy savings, importance of improving use of energy and executive commitment by consistently recognizing accomplishments.
Abide by the relevant legislation and other regulations which apply to the Company or which the Company has committed to observe; especially the requirements arisen from the Act on Pharmaceuticals, the Decree on Good Manufacturing Practice and other guidelines and directives and other requirements related to the occupational safety and the environmental protection.
Constantly educate and train its employees and strongly encourage them to improve the production quality, protect the environment and observe the occupational safety principles; to design the training so as to motivate the employees performing their jobs to prevent or reduce negative impacts of all activities on the environment.
Develop communication and cooperation with the public administration bodies, professional public and other parties concerned with the environmental protection issues. Ikigai Corporation Company is interested in holding open dialogue with the employees and the public, in informing both internal and external stakeholders of the impacts of all the Company’s activities on the environment and in responding to justified suggestions and concerns.
The executive management expects that all the Company employees will accept an opinion that observing the above mentioned principles and objectives is one of the most fundamental duties of every employee in the Company.



1592-23-0.gif

Calcium stearate is a carboxylate of calcium, classified as a calcium soap. It is a component of some lubricants, surfactants, as well as many foodstuffs. It is a white waxy powder.


CONTACT US

  • Overview
  • Product Description
  • Safety
  • Packaging & Delivery
  • Shipping & Payment FAQ
  • Environmental
Technical Information

Synonyms: STEARIC ACID CALCIUM SALT;OCTADECANOIC ACID CALCIUM SALT;CALCIUM OCTADECANOATE;CALCIUM STEARATE;aquacal ;calciumdistearate ;calstar ;dibasiccalciumstearate
CAS No: 1592-23-0
Molecular formula: C36H70CaO4
Molecular weight: 607.03
Purity: N/a
Appearance: White to yellowish-white powder
Melting point: 179 °C
Formulation:PURITY: CALCIUM STEARATE…/IS/ COMPD OF CALCIUM WITH A MIXT OF SOLID ORG ACIDS OBTAINED FROM FATS & CONSISTS CHIEFLY OF VARIABLE PROPORTIONS OF STEARIC & PALMITIC ACIDS… CONTAINS EQUIVALENT OF 9-10.5% OF CALCIUM OXIDE.
SMILES: CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Ca+2]
InChi Key: CJZGTCYPCWQAJB-UHFFFAOYSA-L
Grade Standard: N/A
Brand name: Ikigai ™
Standard: N/A

Shipping & Storage Information

Storage: In bulk, store at about 5-10°C above melting point or at ambient temperature.
Shipping: N/A
Stability (shelf life): N/A
Origin: PRC

Pharmacology

N/A

Bionecessity

N/A

Mechanism of Action

N/A

Overview

Calcium stearate is a carboxylate of calcium, classified as a calcium soap. It is a component of some lubricants, surfactants, as well as many foodstuffs. It is a white waxy powder

Use Classification

N/A

Uses

EPA CPDat Chemical and Product Categories

Category Category Description Categorization Type
Adhesive General adhesives and binding agents for a variety of uses CPCat Cassette
Adhesive, consumer_use Term applied when the only information the source indicates is ‘consumer’ or ‘consumer product’ ; also applied to terms that the source indicates are for consumer use, yet the descriptor term is ambivalent about usage (e.g., cleaning_washing products may be for industrial or consumer use, when the source indicates consumer use, the consumer_use term is also applied) – see appendix for full list of unambiguous consumer related terms plus ambiguous consumer related terms which if indicated are labeled with ‘consumer_use’ CPCat Cassette
Agricultural Relating to agricultural, including the raising and farming of animals and growing of crops CPCat Cassette
Agricultural, animal Related to animals (but non-veterinary) e.g., animal husbandry, farming of animals/animal production, raising of animals for food or fur, animal feed, products for household pets CPCat Cassette
Agricultural, crop Products used on crops, or related to the growing of crops CPCat Cassette

PLASTICS ADDITIVE

Waterproofing fabrics, cement, stucco, explosives; releasing agent for plastic molding powders; lubricant; in pencils and wax crayons

Food grade calcium stearate is used as conditioning agent in certain food and pharmaceutical products

Water repellent; flatting agent in paints; emulsions; cosmetics

STABILIZER IN PLASTIC COMPOUNDING, ESP FOR PVC; INTERNAL LUBRICANT IN PLASTIC COMPOUNDING ESP FOR PVC; IN MFR OF PAPER TO PROMOTE SMOOTH, UNIFORM COATINGS; MOISTURE BARRIER COATING IN FOODS, DRUGS, & COSMETICS; MOLD RELEASE AGENT IN PHARMACEUTICAL PILL & TABLET MFR; IN PAINT & VARNISHES; IN METAL LUBRICATION

As an anti-caking agent in dehydrated vegetable products, salt, and onion and garlic powder

Added to dry lubricants in amounts of 0.25-1.0 wt% to decrease friction

GHS Classification
Pictogram(s)
Irritant
Signal
Warning
GHS Hazard Statements Aggregated GHS information provided by 3721 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria by 3167 of 3721 companies. For more detailed information, please visit ECHA C&L website

Of the 8 notification(s) provided by 554 of 3721 companies with hazard statement code(s):

H319 (97.11%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (99.46%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes P261, P264, P271, P280, P304+P340, P305+P351+P338, P312, P337+P313, P403+P233, P405, and P501

(The corresponding statement to each P-code can be found at the GHS Classification page.)

Accidental Release Measures

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Regulatory Information

FDA Requirements
Calcium stearate is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Calcium stearate is an indirect food additive for use as a component of resinous and polymeric coatings.

Feed-grade calciium stearate is a food additive permitted in feed and drinking water of animals.

Non-Human Toxicity Values

N/A

Environmental Fate/Exposure Summary

Androstenedione’s production and administration as a drug to treat symptoms due to male andropause, dietary supplement, and athletic performance-enhancing drug may result in its release to the environment through various waste streams. Androstenedione is a naturally occurring androgen produced by the adrenal gland and converted to testosterone or estrone. It is produced naturally in humans during the production of testosterone and estrogen. It can be formed in soils via the metabolism of testosterone and estradiol occurring in poultry and livestock manures used as agricultural fertilizers. If released to air an extrapolated vapor pressure of 7.35X10-9 mm Hg at 20 °C indicates androstenedione will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase androstenedione will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and with ozone; the half-lives for these reactions in the air are estimated to be 3.5 hours and 1 day respectively. Particulate-phase androstenedione will be removed from the atmosphere by wet and dry deposition. Androstenedione absorbs light at wavelengths >290 nm, and therefore, may be susceptible to direct photolysis. If released to soil, androstenedione is expected to have no mobility based upon a Koc of 6170. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry’s Law constant of 3.7X10-8 atm-cu m/mole. Androstenedione is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Results of soil column studies using various soils and sands found that half-life of androstenedione ranged from 1.7 to 77 hours. If released into water, androstenedione is expected to adsorb to suspended solids and sediment based upon the Koc. Using OECD Guideline 301B (CO2 Evolution Test), androstenedione reached 79-95% degradation over a 28-day incubation period which classified the compound as readily biodegradable. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Androstenedione in aqueous solutions underwent direct photolysis half-lives ranging from 3.7 to 10.8 hours in direct sunlight. Occupational exposure to androstenedione may occur through dermal contact with this compound at workplaces where androstenedione is produced or used.

Supply Ability:

2000 Metric Ton/Metric Tons per Month

Packaging & Delivery

Packing: Export worthy packing (1kg/Aluminium foil bag;25kg/drum) Or as per customers request.
Ports: port of Hong Kong HKSAR of PRC.,  port of Ningbo, PRC or Any port in China.
Delivery methods:

By couriers:

Question 1: How to start orders for API materials?

Answer: Pro-forma invoice will be sent first after confirmation of the order, enclosed our payment information. Payment by T/T, Paypal, and others. All courier tracking numbers are provided upon shipping.

Question 2: What’s your MOQ?

Answer: The MOQ for this API is 1kg.

Question 3: How to guarantee safe shipment?

Answer: We have shipping insurance. Our experienced team will do the customs documents, generally, it will have no trouble. And we will reship or refund for you if it is seized by our mistake.

 Question 4: How about delivery lead-time?

Answer: Shipping lead time: About 2-5 days after payment confirmed. (Chinese holiday not included), We have long-term relations with shipping agents in main Chinese ports. Full service can be offered, including photos of every shipment, marks, and procedure of loading. General times are gor 1KG-100KG, Within 5-7 days by DHL, UPS, TNT, FEDEX, EMS Over 100KG. within 5-8days by air, 20-40days by sea. More information.

Question 5: Is there a discount?

Answer: Different quantity has a different discount. Please feel free to contact us.

Question 6: How to contact us?

Answer: You can chat with us by Telegram, Email, Skype, Whatsapp, Facebook and other methods – just inquire, we will give a reply ASAP. Please feel free to send your quotations.

Question 7:How do you treat quality complaints?

Answer: Our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. We are competitive in API exporting, Pharmaceutical excipients,  food supplements, dyestuff, veterinary API. Our team has 20 years of experience in this business. Good team for quality control, shipping, and documents.

Question 8: Payment methods you accept?

U.S. funds preferably.

The negative impact of the production of pharmaceutical products on the natural environment is well known. However, this remains largely unregulated, meaning the extremely toxic impact it has on both animals and humans continues with no clear end in sight. As Ikigai Corporation Company Innovator, we are committed to expanding and improving our efforts to safeguard the environment. We accordingly established our environmental management system

Environmental management system
Quality Management, Environmental Management and Occupational Safety Policy

Quality Management, Environmental Management and Occupational Safety Policy
Ikigai Corporation Company is engaged in the production and distribution of pharmaceutical substances and other chemical specialties. As a chemical and pharmaceutical manufacturer, the Company is aware of the impacts of its activities on the product quality, on the environment and the health of its employees, and undertakes to control them, with the aim of constant improvement.

As standards for the implementation and maintenance of the Integrated Management System, the Company has chosen international standards ISO 9001 in the area of quality management (hereinafter called QMS), ISO 14001 for the management of environmental protection (hereinafter called EMS) and specification OHSAS 18000 for ensuring the occupational safety and health protection (hereinafter called SMS). The Integrated Management System applies to all fields of the Company’s activities.

Within this Policy, Ikigai Corporation Company undertakes to:

Constantly improve all of its activities
Executive commitment to continually improve energy efficiency across the entire corporation, including clear processes and tracking systems to identify opportunities
An empowered corporate energy director and energy team supported by sufficient human and financial resources
A corporate energy policy that is accounted for at the top levels of the corporation
Aggressive, numeric energy goals that stretch performance targets to draw out creative innovations for meeting them
Measurement and tracking of energy performance for all energy use, corporationwide, including benchmarking facility performance nationally and globally with similar companies, and a review system with accountability at all levels
Communication of the value of energy savings, importance of improving use of energy and executive commitment by consistently recognizing accomplishments.
Abide by the relevant legislation and other regulations which apply to the Company or which the Company has committed to observe; especially the requirements arisen from the Act on Pharmaceuticals, the Decree on Good Manufacturing Practice and other guidelines and directives and other requirements related to the occupational safety and the environmental protection.
Constantly educate and train its employees and strongly encourage them to improve the production quality, protect the environment and observe the occupational safety principles; to design the training so as to motivate the employees performing their jobs to prevent or reduce negative impacts of all activities on the environment.
Develop communication and cooperation with the public administration bodies, professional public and other parties concerned with the environmental protection issues. Ikigai Corporation Company is interested in holding open dialogue with the employees and the public, in informing both internal and external stakeholders of the impacts of all the Company’s activities on the environment and in responding to justified suggestions and concerns.
The executive management expects that all the Company employees will accept an opinion that observing the above mentioned principles and objectives is one of the most fundamental duties of every employee in the Company.



CS-0021602.gif.png

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener. Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.


CONTACT US

  • Overview
  • Product Description
  • Safety
  • Packaging & Delivery
  • Shipping & Payment FAQ
  • Environmental
Technical Information

Synonyms: calcium lactate, 814-80-2, Calcium dilactate, calcium 2-hydroxypropanoate, Calphosan
CAS No: 814-80-2
Molecular formula: C3H5O2)2Ca·nH2O (n = 0 – 5) or C6H10CaO6
Molecular weight: 218.22 g/mol
Purity: 99%
Appearance: White to cream crystalline powder (est)
Melting point: 240 °C
Formulation: CALCIUM LACTATE USP; POWDER USP, TABLETS USP, 325 MG (42.25 MG CALCIUM), & 650 MG (84.5 MG CALCIUM)
SMILES: CC(C(=O)[O-])O.CC(C(=O)[O-])O.[Ca+2]
InChi Key: MKJXYGKVIBWPFZ-UHFFFAOYSA-L
Grade Standard: Food Grade, Medicine Grade
Brand name: Ikigai ™
Standard: USP, Ph. Eur., JP Etc

Shipping & Storage Information

Storage: Store at room temperature
Shipping: Room Temperature (may vary elsewhere)
Stability (shelf life): AQ SOLN ARE PRONE TO BECOME MOLDY.
Origin: PRC

Pharmacology

Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively [F59].

Bionecessity

N/A

Mechanism of Action

In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid. Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways [F59]. Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis [F59].

Overview

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener. Calcium lactate is also found in daily dietary supplements as a source of calcium. It is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.

Use Classification

JECFA Functional Classes
Food Additives: ACIDITY_REGULATOR; FLOUR_TREATMENT_AGENT; YEAST_FOOD

Uses

EPA CPDat Chemical and Product Categories

Category Category Description Categorization Type
Drug, dietary_supplement Pharmaceutical related CPCat Cassette
Drug, inactive_ingredient Pharmaceutical related CPCat Cassette
Facility, food_production Related to food production (restaurants, catering, etc) CPCat Cassette
Feed, animal Related to animals (but non-veterinary) e.g., animal husbandry, farming of animals/animal production, raising of animals for food or fur, animal feed, products for household pets CPCat Cassette
Food_additive Includes spices, extracts, colorings, flavors, etc added to food for human consumption CPCat Cassette
General Manufacturing Information
Industry Processing Sectors

Agriculture, forestry, fishing and hunting
EPA TSCA Commercial Activity Status
Propanoic acid, 2-hydroxy-, calcium salt (2:1): ACTIVE
Commercial baking powder contains 2.5% calcium lactate.

Technological superiority and innovation
API manufacturing
GHS Classification
Pictogram(s)
Irritant
Signal
Warning
GHS Hazard Statements Aggregated GHS information provided by 86 companies from 4 notifications to the ECHA C&L Inventory.

Reported as not meeting GHS hazard criteria by 7 of 86 companies. For more detailed information, please visit ECHA C&L website

Of the 3 notification(s) provided by 79 of 86 companies with hazard statement code(s):

H319 (98.73%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes P264, P280, P305+P351+P338, and P337+P313

(The corresponding statement to each P-code can be found at the GHS Classification page.)

Accidental Release Measures

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Regulatory Information

FDA Requirements
Substance added directly to human food affirmed as generally recognized as safe (GRAS).
21 CFR 184.1207 (4/1/99)
Calcium lactate used as a general purpose food additive is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
21 CFR 582.1207 (4/1/99)

Non-Human Toxicity Values

CALCIUM LACTATE GIVEN ORALLY TO RABBITS @ 2.5 G/KG/DAY FOR 15 DAYS CAUSED HYPERPLASIA OF THE THYROID PARENCHYMA AND INCR RNA CONTENT IN THE THYROID MICROFOLLICLES AND FOLLICULAR EPITHELIUM.

Environmental Fate/Exposure Summary

Androstenedione’s production and administration as a drug to treat symptoms due to male andropause, dietary supplement, and athletic performance-enhancing drug may result in its release to the environment through various waste streams. Androstenedione is a naturally occurring androgen produced by the adrenal gland and converted to testosterone or estrone. It is produced naturally in humans during the production of testosterone and estrogen. It can be formed in soils via the metabolism of testosterone and estradiol occurring in poultry and livestock manures used as agricultural fertilizers. If released to air an extrapolated vapor pressure of 7.35X10-9 mm Hg at 20 °C indicates androstenedione will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase androstenedione will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and with ozone; the half-lives for these reactions in the air are estimated to be 3.5 hours and 1 day respectively. Particulate-phase androstenedione will be removed from the atmosphere by wet and dry deposition. Androstenedione absorbs light at wavelengths >290 nm, and therefore, may be susceptible to direct photolysis. If released to soil, androstenedione is expected to have no mobility based upon a Koc of 6170. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry’s Law constant of 3.7X10-8 atm-cu m/mole. Androstenedione is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Results of soil column studies using various soils and sands found that half-life of androstenedione ranged from 1.7 to 77 hours. If released into water, androstenedione is expected to adsorb to suspended solids and sediment based upon the Koc. Using OECD Guideline 301B (CO2 Evolution Test), androstenedione reached 79-95% degradation over a 28-day incubation period which classified the compound as readily biodegradable. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Androstenedione in aqueous solutions underwent direct photolysis half-lives ranging from 3.7 to 10.8 hours in direct sunlight. Occupational exposure to androstenedione may occur through dermal contact with this compound at workplaces where androstenedione is produced or used.

Supply Ability:

2000 Metric Ton/Metric Tons per Month

Packaging & Delivery

Packing: Export worthy packing (1kg/Aluminium foil bag;25kg/drum) Or as per customers request.
Ports: port of Hong Kong HKSAR of PRC.,  port of Ningbo, PRC or Any port in China.
Delivery methods:

By couriers:

Question 1: How to start orders for API materials?

Answer: Pro-forma invoice will be sent first after confirmation of the order, enclosed our payment information. Payment by T/T, Paypal, and others. All courier tracking numbers are provided upon shipping.

Question 2: What’s your MOQ?

Answer: The MOQ for this API is 1kg.

Question 3: How to guarantee safe shipment?

Answer: We have shipping insurance. Our experienced team will do the customs documents, generally, it will have no trouble. And we will reship or refund for you if it is seized by our mistake.

 Question 4: How about delivery lead-time?

Answer: Shipping lead time: About 2-5 days after payment confirmed. (Chinese holiday not included), We have long-term relations with shipping agents in main Chinese ports. Full service can be offered, including photos of every shipment, marks, and procedure of loading. General times are gor 1KG-100KG, Within 5-7 days by DHL, UPS, TNT, FEDEX, EMS Over 100KG. within 5-8days by air, 20-40days by sea. More information.

Question 5: Is there a discount?

Answer: Different quantity has a different discount. Please feel free to contact us.

Question 6: How to contact us?

Answer: You can chat with us by Telegram, Email, Skype, Whatsapp, Facebook and other methods – just inquire, we will give a reply ASAP. Please feel free to send your quotations.

Question 7:How do you treat quality complaints?

Answer: Our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. We are competitive in API exporting, Pharmaceutical excipients,  food supplements, dyestuff, veterinary API. Our team has 20 years of experience in this business. Good team for quality control, shipping, and documents.

Question 8: Payment methods you accept?

U.S. funds preferably.

The negative impact of the production of pharmaceutical products on the natural environment is well known. However, this remains largely unregulated, meaning the extremely toxic impact it has on both animals and humans continues with no clear end in sight. As Ikigai Corporation Company Innovator, we are committed to expanding and improving our efforts to safeguard the environment. We accordingly established our environmental management system

Environmental management system
Quality Management, Environmental Management and Occupational Safety Policy

Quality Management, Environmental Management and Occupational Safety Policy
Ikigai Corporation Company is engaged in the production and distribution of pharmaceutical substances and other chemical specialties. As a chemical and pharmaceutical manufacturer, the Company is aware of the impacts of its activities on the product quality, on the environment and the health of its employees, and undertakes to control them, with the aim of constant improvement.

As standards for the implementation and maintenance of the Integrated Management System, the Company has chosen international standards ISO 9001 in the area of quality management (hereinafter called QMS), ISO 14001 for the management of environmental protection (hereinafter called EMS) and specification OHSAS 18000 for ensuring the occupational safety and health protection (hereinafter called SMS). The Integrated Management System applies to all fields of the Company’s activities.

Within this Policy, Ikigai Corporation Company undertakes to:

Constantly improve all of its activities
Executive commitment to continually improve energy efficiency across the entire corporation, including clear processes and tracking systems to identify opportunities
An empowered corporate energy director and energy team supported by sufficient human and financial resources
A corporate energy policy that is accounted for at the top levels of the corporation
Aggressive, numeric energy goals that stretch performance targets to draw out creative innovations for meeting them
Measurement and tracking of energy performance for all energy use, corporationwide, including benchmarking facility performance nationally and globally with similar companies, and a review system with accountability at all levels
Communication of the value of energy savings, importance of improving use of energy and executive commitment by consistently recognizing accomplishments.
Abide by the relevant legislation and other regulations which apply to the Company or which the Company has committed to observe; especially the requirements arisen from the Act on Pharmaceuticals, the Decree on Good Manufacturing Practice and other guidelines and directives and other requirements related to the occupational safety and the environmental protection.
Constantly educate and train its employees and strongly encourage them to improve the production quality, protect the environment and observe the occupational safety principles; to design the training so as to motivate the employees performing their jobs to prevent or reduce negative impacts of all activities on the environment.
Develop communication and cooperation with the public administration bodies, professional public and other parties concerned with the environmental protection issues. Ikigai Corporation Company is interested in holding open dialogue with the employees and the public, in informing both internal and external stakeholders of the impacts of all the Company’s activities on the environment and in responding to justified suggestions and concerns.
The executive management expects that all the Company employees will accept an opinion that observing the above mentioned principles and objectives is one of the most fundamental duties of every employee in the Company.



62-54-4.gif

Calcium Acetate is a calcium salt of acetic acid. Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. Calcium acetate is administered orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.


CONTACT US

  • Overview
  • Product Description
  • Safety
  • Packaging & Delivery
  • Shipping & Payment FAQ
  • Environmental
Technical Information

Synonyms:Calcium acetate

62-54-4

Calcium diacetate

Acetic acid, calcium salt

Lime acetate
CAS No: 62-54-4
Molecular formula: Anhydrous:C4H6O4Ca or C4H6O4.Ca or (CH3OO)2Ca or Ca(C2H3O2)2 or C4H6CaO4
Molecular weight: 158.17 g/mol
Purity: 99%
Appearance: White to Off-White Solid
Melting point: 160°C (dec.)
Formulation: Grades: Technical (80% basis); reagent; CP; pure; brown; gray; FCC /Monohydrate/
SMILES: CC(=O)[O-].CC(=O)[O-].[Ca+2]
InChi Key: VSGNNIFQASZAOI-UHFFFAOYSA-L
Grade Standard: N/A
Brand name: Ikigai ™
Standard: CP, USP, BP.

Shipping & Storage Information

Storage: Hygroscopic
Shipping: Room Temperature, under inert atmosphere
Stability (shelf life): Stable under ordinary conditions of use and storage. Very hygroscopic.
Origin: PRC

Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product. Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage.

Pharmacology

Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.

Bionecessity

N/A

Mechanism of Action

Calcium acetate and other calcium salts are phosphate binders. They work by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.

Overview

Calcium Acetate is a calcium salt of acetic acid. Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. Calcium acetate is administered orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.

Use Classification

EPA Safer Chemical Functional Use Classes

Processing Aids and Additives
Safer Chemical Classes

Green circle Green circle – The chemical has been verified to be of low concern
JECFA Functional Classes

Food Additives: ACIDITY_REGULATOR; PRESERVATIVE; STABILIZER

Uses
Category Category Description Categorization Type
Antifreezing Antifreezing agents, or de-icing products CPCat Cassette
Consumer_use Term applied when the only information the source indicates is ‘consumer’ or ‘consumer product’ ; also applied to terms that the source indicates are for consumer use, yet the descriptor term is ambivalent about usage (e.g., cleaning_washing products may be for industrial or consumer use, when the source indicates consumer use, the consumer_use term is also applied) – see appendix for full list of unambiguous consumer related terms plus ambiguous consumer related terms which if indicated are labeled with ‘consumer_use’ CPCat Cassette
Drug Drug product, or related to the manufacturing of drugs; modified by veterinary, animal, or pet if indicated by source CPCat Cassette
Drug, antihyperphosphatemic Pharmaceutical related CPCat Cassette
Drug, chelator Pharmaceutical related CPCat Cassette

Use Classification

Food additives

Mfr of acetic acid, acetone; in dying, tanning and curing skins; in lubricants; as food stabilizer; as corrosion inhibitor.
Budavari, S. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 270

One of the more commonly used antifoam additives in /modern/ formulated antifreezes
Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V3 88

Dry distillation of calcium acetate with calcium formate produces acetaldehyde
CONSIDINE. CHEMICAL AND PROCESS TECHNOL ENCYC 1974 p.68

Mfg of acetate; mordant in printing of textiles; stabilizer in resins; additive to calcium soap lubricants; food additive, as antimold agent in bakery goods. /Monohydrate/
Lewis, R.J., Sr (Ed.). Hawley’s Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 193

Firming agent for potatoes, stabilizer and thickener for gelatins and puddings; ingredient of skin preparations, antiseptics and blood coagulant tablets
CHEMCYCLOPEDIA 1986 p.168

MEDICATION

Esterification catalyst
Ashford, R.D. Ashford’s Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 166

Technological superiority and innovation
API manufacturing
GHS Classification
GHS Hazard Statements Not Classified

Reported as not meeting GHS hazard criteria by 432 of 475 companies (only ~ 9.1% companies provided GHS information). For more detailed information, please visit ECHA C&L website

Accidental Release Measures

Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Regulatory Information

FDA Requirements
Substance added directly to human food affirmed as generally recognized as safe (GRAS).
21 CFR 184.1185 (4/1/99)

Calcium acetate is an indirect food additive for use as a component of resinous and polymeric coatings.
21 CFR 175.300 (4/1/99)

Calcium acetate used as a sequestrant is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Non-Human Toxicity Values

LD50 Mouse ip 75 mg/kg

LD50 Mouse iv 52 mg/kg

Environmental Fate/Exposure Summary

Androstenedione’s production and administration as a drug to treat symptoms due to male andropause, dietary supplement, and athletic performance-enhancing drug may result in its release to the environment through various waste streams. Androstenedione is a naturally occurring androgen produced by the adrenal gland and converted to testosterone or estrone. It is produced naturally in humans during the production of testosterone and estrogen. It can be formed in soils via the metabolism of testosterone and estradiol occurring in poultry and livestock manures used as agricultural fertilizers. If released to air an extrapolated vapor pressure of 7.35X10-9 mm Hg at 20 °C indicates androstenedione will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase androstenedione will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and with ozone; the half-lives for these reactions in the air are estimated to be 3.5 hours and 1 day respectively. Particulate-phase androstenedione will be removed from the atmosphere by wet and dry deposition. Androstenedione absorbs light at wavelengths >290 nm, and therefore, may be susceptible to direct photolysis. If released to soil, androstenedione is expected to have no mobility based upon a Koc of 6170. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry’s Law constant of 3.7X10-8 atm-cu m/mole. Androstenedione is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Results of soil column studies using various soils and sands found that half-life of androstenedione ranged from 1.7 to 77 hours. If released into water, androstenedione is expected to adsorb to suspended solids and sediment based upon the Koc. Using OECD Guideline 301B (CO2 Evolution Test), androstenedione reached 79-95% degradation over a 28-day incubation period which classified the compound as readily biodegradable. Volatilization from water surfaces is not expected to be an important fate process based upon this compound’s estimated Henry’s Law constant. An estimated BCF of 30 suggests the potential for bioconcentration in aquatic organisms is low to moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Androstenedione in aqueous solutions underwent direct photolysis half-lives ranging from 3.7 to 10.8 hours in direct sunlight. Occupational exposure to androstenedione may occur through dermal contact with this compound at workplaces where androstenedione is produced or used.

Supply Ability:

2000 Metric Ton/Metric Tons per Month

Packaging & Delivery

Packing: Export worthy packing (1kg/Aluminium foil bag;25kg/drum) Or as per customers request.
Ports: port of Hong Kong HKSAR of PRC.,  port of Ningbo, PRC or Any port in China.
Delivery methods:

By couriers:

Question 1: How to start orders for API materials?

Answer: Pro-forma invoice will be sent first after confirmation of the order, enclosed our payment information. Payment by T/T, Paypal, and others. All courier tracking numbers are provided upon shipping.

Question 2: What’s your MOQ?

Answer: The MOQ for this API is 1kg.

Question 3: How to guarantee safe shipment?

Answer: We have shipping insurance. Our experienced team will do the customs documents, generally, it will have no trouble. And we will reship or refund for you if it is seized by our mistake.

 Question 4: How about delivery lead-time?

Answer: Shipping lead time: About 2-5 days after payment confirmed. (Chinese holiday not included), We have long-term relations with shipping agents in main Chinese ports. Full service can be offered, including photos of every shipment, marks, and procedure of loading. General times are gor 1KG-100KG, Within 5-7 days by DHL, UPS, TNT, FEDEX, EMS Over 100KG. within 5-8days by air, 20-40days by sea. More information.

Question 5: Is there a discount?

Answer: Different quantity has a different discount. Please feel free to contact us.

Question 6: How to contact us?

Answer: You can chat with us by Telegram, Email, Skype, Whatsapp, Facebook and other methods – just inquire, we will give a reply ASAP. Please feel free to send your quotations.

Question 7:How do you treat quality complaints?

Answer: Our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss. We are competitive in API exporting, Pharmaceutical excipients,  food supplements, dyestuff, veterinary API. Our team has 20 years of experience in this business. Good team for quality control, shipping, and documents.

Question 8: Payment methods you accept?

U.S. funds preferably.

The negative impact of the production of pharmaceutical products on the natural environment is well known. However, this remains largely unregulated, meaning the extremely toxic impact it has on both animals and humans continues with no clear end in sight. As Ikigai Corporation Company Innovator, we are committed to expanding and improving our efforts to safeguard the environment. We accordingly established our environmental management system

Environmental management system
Quality Management, Environmental Management and Occupational Safety Policy

Quality Management, Environmental Management and Occupational Safety Policy
Ikigai Corporation Company is engaged in the production and distribution of pharmaceutical substances and other chemical specialties. As a chemical and pharmaceutical manufacturer, the Company is aware of the impacts of its activities on the product quality, on the environment and the health of its employees, and undertakes to control them, with the aim of constant improvement.

As standards for the implementation and maintenance of the Integrated Management System, the Company has chosen international standards ISO 9001 in the area of quality management (hereinafter called QMS), ISO 14001 for the management of environmental protection (hereinafter called EMS) and specification OHSAS 18000 for ensuring the occupational safety and health protection (hereinafter called SMS). The Integrated Management System applies to all fields of the Company’s activities.

Within this Policy, Ikigai Corporation Company undertakes to:

Constantly improve all of its activities
Executive commitment to continually improve energy efficiency across the entire corporation, including clear processes and tracking systems to identify opportunities
An empowered corporate energy director and energy team supported by sufficient human and financial resources
A corporate energy policy that is accounted for at the top levels of the corporation
Aggressive, numeric energy goals that stretch performance targets to draw out creative innovations for meeting them
Measurement and tracking of energy performance for all energy use, corporationwide, including benchmarking facility performance nationally and globally with similar companies, and a review system with accountability at all levels
Communication of the value of energy savings, importance of improving use of energy and executive commitment by consistently recognizing accomplishments.
Abide by the relevant legislation and other regulations which apply to the Company or which the Company has committed to observe; especially the requirements arisen from the Act on Pharmaceuticals, the Decree on Good Manufacturing Practice and other guidelines and directives and other requirements related to the occupational safety and the environmental protection.
Constantly educate and train its employees and strongly encourage them to improve the production quality, protect the environment and observe the occupational safety principles; to design the training so as to motivate the employees performing their jobs to prevent or reduce negative impacts of all activities on the environment.
Develop communication and cooperation with the public administration bodies, professional public and other parties concerned with the environmental protection issues. Ikigai Corporation Company is interested in holding open dialogue with the employees and the public, in informing both internal and external stakeholders of the impacts of all the Company’s activities on the environment and in responding to justified suggestions and concerns.
The executive management expects that all the Company employees will accept an opinion that observing the above mentioned principles and objectives is one of the most fundamental duties of every employee in the Company.



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